• Active B Complex
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Active B Complex

Homocysteine Support

$16.00 USD
$16.00 USD
B vitamins work together to support energy production, maintain healthy homocysteine metabolism, and promote the health of the nervous system.* Formulated with activated forms of B6, B12, and Quatrefolic®, a patented form of methylfolate that has demonstrated greater bioavailability than dietary folate.
Certifications
Non-GMO
Certified GMP
Lab Tested
Manufactured in USA
Allergen Information
No allergen information available for this product.
Supplement Facts Panel

Active B Complex

Serving Size: 1 capsule
Amount Per Serving Daily Value
Vitamin B1 (as thiamin hydrochloride) 25 mg 2083%
Vitamin B2 (as riboflavin) 25 mg 1923%
Vitamin B3 (as niacinamide) 50 mg NE 313%
Vitamin B6 (as pyridoxyl-5-phosphate) 25 mg 1471%
Folate [as Quatrefolic®, (6S)-5-Methyltetrahydrofolic acid, glucosamine salt] 400 mcg DFE 100%
Vitamin B12 (as methylcobalamin) 500 mcg 20833%
Biotin 500 mcg 1667%
Pantothenic Acid (as d-calcium pantothenate) 50 mg 1000%
Other Ingredients: Rice Powder , Vegetable Capsule (calcium carbonate) and Silicon Dioxide
    Active B Complex

    FAQs

    What are B-complex vitamins, and why are they considered "active" in certain supplements?

    B-complex includes eight essential water-soluble vitamins (B1, B2, B3, B5, B6, B7, B9, B12). Active B-Complex supplements use pre-converted, coenzyme forms like P-5-P and methylcobalamin to enhance bioavailability and bypass metabolic conversions that some individuals perform inefficiently.

    Why is the "active" form of Vitamin B6 (P-5-P) considered clearly superior to pyridoxine?

    P-5-P is the biologically active form of B6 and is safer and more effective than pyridoxine, which can cause neurotoxicity at high doses and may inhibit P-5-P activity. P-5-P bypasses liver conversion and has shown minimal toxicity in studies.

    What is the main debate surrounding folic acid versus L-methylfolate (active B9), especially concerning genetic factors?

    Folic acid requires conversion via the MTHFR enzyme to become active, whereas L-methylfolate is bioavailable and can bypass genetic polymorphisms like MTHFR C677T. Methylfolate is favored in personalized medicine for its effectiveness in individuals with reduced enzyme function.

    How do B vitamins contribute to energy metabolism, and what is the role of an Active B-Complex in this process?

    B vitamins act as coenzymes in cellular energy production. An Active B-Complex provides them in ready-to-use forms, facilitating ATP generation from macronutrients. Key examples include B1 for glycolysis, B2 and B3 for the electron transport chain, and B5 and B7 for metabolic reactions.

    What is the methylation cycle, and what critical role do B vitamins play in it?

    The methylation cycle uses B6, B9, and B12 to regulate DNA repair, gene expression, neurotransmitter metabolism, and detoxification. These vitamins support homocysteine recycling and SAMe production. Deficiencies or MTHFR polymorphisms can impair this cycle and increase disease risk.

    How do B vitamins support neurological health and mental well-being?

    B vitamins support neurotransmitter synthesis, myelin formation, and brain energy metabolism. P-5-P (B6), methylfolate (B9), and methylcobalamin (B12) are especially important for mood, memory, and neurological integrity. Deficiencies are linked to depression and cognitive decline.

    What are the main clinical applications for Active B-Complex supplements, and what does the evidence suggest?

    Clinical applications include support for peripheral neuropathy, cognitive decline, mood disorders, cardiovascular health, and fatigue. Evidence supports benefits in individuals with low baseline B-vitamin status, MTHFR polymorphisms, or elevated homocysteine levels.

    What are the safety considerations and potential drug interactions associated with high-dose Active B-Complex supplementation?

    While generally safe, high doses of B6 (pyridoxine) can cause neuropathy, and high niacin can lead to flushing and liver stress. Drug interactions exist with medications like metformin (B12), phenytoin (folate), and statins (niacin). Medical supervision is advised for high-potency use.

    Learn More

    How Does It Work?

    Think of B vitamins as essential parts for your body's engine. They don't provide energy themselves, but they are crucial for converting the food you eat into cellular fuel. They also help build important brain chemicals like serotonin and dopamine. An Active B-Complex essentially gives your body pre-fitted parts, bypassing the conversion steps that can sometimes be inefficient due to genetics, age, or lifestyle factors. This allows for better absorption and immediate use by your cells.

    What the Science Says: Key Benefits

    While research is ongoing, human clinical studies point to some exciting benefits:

    • Stress Reduction: Feeling overwhelmed? A large-scale review of 16 clinical trials found that B-complex supplementation significantly helps reduce feelings of stress in both healthy and at-risk individuals.
    • Cardiovascular Support: A recent randomized controlled trial showed that a combination of active B vitamins (methylfolate, P-5-P, and methylcobalamin) effectively lowered both homocysteine and LDL ("bad") cholesterol in people with common genetic variants that affect vitamin metabolism.
    • Improved Exercise Performance: A 2023 clinical trial found that healthy adults taking a B-complex supplement for 28 days showed significantly improved endurance and lower levels of fatigue-related markers after exercise.

    Who Might Benefit Most?

    While many people can get enough B vitamins from a balanced diet, an active B-complex might be particularly useful for:

    • Individuals dealing with high levels of stress.
    • People with common genetic variants, like MTHFR, that can make it harder to activate certain B vitamins.
    • Those looking to support their energy metabolism and physical endurance.
    • Older adults, who may have reduced absorption of vitamin B12.

    A Note on Safety

    B vitamins are water-soluble, meaning your body typically excretes what it doesn’t use. However, very high doses of certain B vitamins can have side effects. It's especially important that high-dose B6 is in the P-5-P form, which is considered safer than the standard pyridoxine form. As with any supplement, it is best to consult with a healthcare professional before starting, especially if you are pregnant, nursing, or taking other medications.

    The Takeaway

    An Active B-Complex offers a targeted, science-informed approach to supplementation. By providing B vitamins in their most bioavailable forms, it can help optimize energy, mood, and overall metabolic health. It’s a promising tool to consider as part of a comprehensive wellness plan, guided by your personal health needs and a professional's advice.

    Guarantees

    • Practitioner Guided

      We guarantee that every supplement pack you receive is an exact reflection of the personalized protocol designed by your trusted healthcare provider

    • Professional-Grade

      We guarantee that every supplement in your daily pack is sourced from top-tier, professional-grade manufacturers

    • Convenience

      We guarantee to simplify your daily health routine

    • Precision & Consistency

      We guarantee the accuracy of every pack and the reliability of our service

    *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

    †Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.